SAR of Genotoxic Carcinogens

XCH2- XCH2O- XCH2S- XCH2N- XCH2CHCH- XCH2ArX = CI,Br,orI 

Direct-Acting SA Concern-Enhancing or Boosting Rules 

Direct-Acting SA Concern-Mitigating or Busting Rules 

Other structural features that may enhance carcinogenic potential include (a) blocking of the L-region by ring fusion to prevent detoxification and (b) a methyl group at the immediate vicinity of bay region (e.g., 12-methyl of benz[a]anthracene or 

5-methyl of chrysene) to slightly distort the bay region. On the other hand, the structural features that may reduce or eliminate carcinogenic potential include 

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