Sanguinarine carcinoma cells

Sanguinarine, isolated from the root of Sanguinaria canadensis, possesses both anti-inflammatory and antioxidant properties. In addition, this alkaloid has displayed anti-proliferative and apoptotic effects against human epidermoid carcinoma cells and normal human epidermal keratinocytes. While treatment with sanguinarine has been shown to decrease the viability of both kinds of cells, this loss of viability occurred at lower doses of the compound and was much more pronounced in the carcinoma cells than in the normal keratinocytes [108]. [Pg.164]

Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dejjendent kinase machinery. [Pg.782]

W. Choi, G. Kim, W. Lee, and Y. Choi, Sanguinarine, a benzophenanthridine alkaloid, induces apoptosis in MDA-MB -231 human breast carcinoma cells through a reactive oxygen species -mediated mitochondrial pathway. Chemotherapy, 54 (2008) 279-87. [Pg.25]

Sanguinarine has broad in vitro antibacterial activity and also displays antifungal and antitrichomonas activities and local anesthetic property. It has also shown inhibition of NF-kB, anti-inflammatory and antioxidant activities, and antitumor activity in animals. At micromolar concentrations in vitro, sanguinarine inhibited the growth of human epidermoid carcinoma cells through the induction of apoptosis.Protopine has shown platelet aggregation-inhibitory effects in animals."... [Pg.102]

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