Salbutamol inhaled

Zainudin, B.M.Z., Biddiscombe. M., Tolfree, S.E.J., Short, M., and Spiro, S.G., Comparison of bronchodilator responses and deposition patterns of salbutamol inhaled from a pressurized metered dose inhaler, as a dry powder, and as a nebulized solution, Thorax, 45 469-473 (1990). 

Pitcairn, G., Lunghetti, G., Ventura, P., and Newman, S.P., A comparison of the lung deposition of salbutamol inhaled from a new powder inhaler at two inhaled flow rates, Int. J. Pharm., 102 11-18 (1994). 

Aerosols are suspension of fine, solid or liquid particles in a medium like air or oxygen and administered with the help of nebulizers. They are used to apply drugs to the respiratory tract in asthmatic patients e.g. Asthalin (salbutamol) inhaler, Fintal (sodium cromoglycate) inhaler. 

Mr JA s previous medical history includes porphyria and childhood asthma. His past drug history comprises salbutamol inhaler and beclometasone inhaler for childhood asthma. 

Mr DP, 35 years, has been taking asthma medication for 12 years and occasionally also suffers from eczema. His regular prescription is for salbutamol inhaler (100 micrograms/metered inhalation) 1-2 puffs as required and Clenil-Modulite (100 micrograms/dose) 2 puffs twice daily. Today he presents in your pharmacy with a new prescription for Betnovate scalp application. 

The efficacy and safety of salbutamol inhaled using a dry powder inhaler has been compared with salbutamol inhaled using a pressurized metered-dose inhaler (pMDI) in a randomized, open, crossover study in 12 patients with moderate to severe asthma. A total of 1600 micrograms of salbutamol was given on two separate days in a cumulative dose fashion in increments of 100,100,200, 400, and 800 micrograms at 3-minute intervals. FEVi rose progressively with each increment. The dose-response curves showed that powdered salbutamol was 3.0 times as potent (Cl = 1.8,5.8) as salbutamol from... 

Duncan D, Paterson I, Harris D, Crompton G. Comparison of the effects of salbutamol inhaled as a dry powder and by conventional pressurized aerosol. Br J Clin Pharmacol 1977 4 669-671. 

Tal A, Golan H, Aviram M. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction. J Pediatr 1996 128 479-484. 

Consistent dosing through to the end of canister life The valves currently used on salbutamol CFC pMDIs do not uniformly deliver drug when the canister is nearly empty because of inconsistency of filling up the metering tank. This is referred to as tail-off. If the canister is used beyond the label number of doses, the deUveied dose may become unpredictable and subject to wide variation (85). The tail-off pattern of the new CFC-free salbutamol inhaler (Airomir) shows that once valve delivery... 

Harvey JE, Tattersfleld AE. Airway response to salbutamol effect of regular salbutamol inhalations in normal atopic and asthmatic subjects. Thorax 1982 37 280-287. 

Vidgren M, Vidgren P, Hyvarinen L, SUvasti M, Tukiainen H. Deposition and clinical response of 99m Tc-labeUed salbutamol inhaled from a novel multiple dose powder inhaler. Am Rev Respir Dis 1993 147(suppl) A58. 

Patane S, Marte F, La Rosa FC, La Rocca R. Atrial fibrillation associated with chocolate intake abuse and chronic salbutamol inhalation abuse. Int J Cardiol 2010 145(2) e74-6. 

Terrier-Lenglet A, Derra HC, Devoldere C, Dufour V, Gras V, Andrejak M. Misuse of a salbutamol inhaler causing skin bums. Therapie 2012 67(1) 59-61. 

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