Sakurai MCRs

SCHEME 12.14 The first chiral aldehyde-based Sakurai MCR reported by Marko et al. 

In this chapter, four different essential MCRs have been compiled, in particular Radziszewski, (aza-)Sakurai, Gewald, and Kabachnik-Fields reactions (Scheme 12.31). These reactions give access to five types of products substituted imidazoles, homoallylic ethers(amines), 2-aminothiophene derivatives, and a-aminophosphonates. The interest in these moieties is broadly recognized in the scientific community, since, among other properties, they are found in the structure of numerous biologically active natural or synthesized molecules. 

The last category is the class of MCRs catalyzed by organometallic species (MC-MCRs). MC-MCRs include the palladium-catalyzed multicomponent reaction of vinyl compounds [52], the three-component Sakurai allylation reaction [53], metal-catalyzed three-component reactions between alkynes, amines, and... 

---