Safety in Fluid Bed

With the introduction of potent and costly drug substances, the 2 bar design is being replaced with a 10 bar design and higher, based on the specific mixtures of the product(s) being processed. These units can withstand explosions up to 10 bar. Most of the pharmaceutical dust explosions studied (143) show the overpressure reaching 

In case of granulation requiring flammable solvents, process air and nozzle atomization air are replaced by an inert gas such as nitrogen and the system is designed as a closed cycle with a solvent recovery capability (144). A number of approaches can be taken to handle solvent from the process. Table 6 summarizes various methods for solvent emission control systems. 

In 1994 European parliament issued the ATEX directive (145) on the approximation of the laws of the member states, concerning equipment and protective systems intended for use in potentially explosive atmospheres. The scope, these regulations specifically require protective systems, intended to halt incipient explosions immediately 

Fluidbed dryer, fan and dryer protected by a Explosionbarrier value Ventex-ESI-D valve, inlet devices protected by a Ventex-ESI-C or a Venlex-ESI-E 

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