Ryanodine-type compounds

Ryanodine-type compounds act primarily at the Ca2+ release channel in both mammals and insects [12], Ryanodol-type compounds, however, are more selective toxicants for insects than they are for mammals, suggesting a different mode of action for these compounds [13, 14]. 

Last but not least, it was also shown that fiubendiamide and its sulfoxide are specihc to insect ryanodine receptors and do not affect mammalian ryanodine receptors. Even high concentrations of fiubendiamide sulfoxide applied on differentiated mouse muscle C2C12 cells which express the muscle Subtype 1 and Subtype 111 did not either elicit Ca signals nor did they prevent the Ca transients elicited by caffeine (Figure 9). Therefore, we conclude that fiubendiamide and related compounds do not affect mammalian RyR Type I and III. These observations provide a good explanation for the excellent toxicological profile observed in the case of fiubendiamide. 

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