Rufloxacin Theophylline

Carlucci, G. Mazzeo, P. Palumbo, G. Simultaneous determination of rufloxacin and theophylline hy high-performance hquid chromatography in human plasma. Analyst, 1995, 120, 2493—2495... 

Cesana M, Broccali G, Imbimbo BP, Crema A. Effect of single doses of rufloxacin on the disposition of theophylline and caffeine after single administration. IntJClin Pharmacol Ther 7ox/co7(1991) 29, 133-8. 

Theophylline serum levels can be markedly increased in most patients by enoxacin. Pipemidic acid and clinafloxacin probably interact similarly. Theophylline levels can also be markedly increased in some patients by ciprofloxacin, and possibly pe-floxacin. Norfloxacin, ofloxacin, pazufloxacin, or prulifloxacin normally cause a much smaller rise in theophylline levels. However, serious toxicity has been seen in few patients given norfloxacin. Fleroxacin, flumequine, gatifloxacin, gemifloxacin, levofloxacin, lomefloxacin, moxifloxacin, nalidixic acid, rufloxacin, spar-floxacin and trovafloxacin appear not to interact. 

Kinzig-Schlppers M, Fuhr U, Cesana M, Muller C, Staib AH, Rietbrock S. Sorgel F. Absence of effect of rufloxacin on theophylline pharmacokinetics in steady state. Antimicrob Agents Chemother (1998) 42, 2359-64. 

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See also in sourсe #XX -- [ ]

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