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Rufloxacin

A variation on ofloxacin is mfloxacin (20) this compound lacks the methyl group on the 1,8-bridge and contains a sulfur in place of the oxygen attached to the 8-position. Rufloxacin, although less potent than ofloxacin, is well absorbed and has longer half life than does ofloxacin (44—46). [Pg.454]

More then a dozen representatives of the above ring systems were introduced into the human therapy. Actisomide (2) and trequinsin (3) are used as antiarrhytmic and antihypertensive agents, respectively. Sunepitron (4), a a 2-adrenoceptor antagonist, is under clinical trials for the treatment of anxiety and depression. Representatives of the third generation of antibacterial quinolone-3-carboxylic acids the blockbluster ofloxacin (5), its levorotatory enantiomer, levofloxacin (6), and rufloxacin (7) have gained wide acceptance for the treatment of bacterial infections of the respiratory and urinary tracts, skin, and soft tissues, as well as sexually transmitted diseases, and pazufloxacin (8) is under development. Praziquantel (9) is widely applied for the treatment of schistosomes- and cestode-caused infection in both veterinary and human therapies (Scheme 4). [Pg.225]

Rufloxacin degraded with UVA radiation under anaerobic and aerobic conditions by decarboxylation (98MI5). [Pg.295]

Treatment of quinolone disulfide 330 with NaH yielded rufloxacin ethyl ester (331) (97USP5703233). [Pg.296]

C5H12N2 109-01-3) see Azimilide hydrochloride Chlorcyclizine Clozapine Cyclizine Diethylcarbamazine Fleroxacin Hexocyclium metilsulfate Levofloxacin Loprazolam Loxapine Ofloxacin Olanzapine Pefloxacin Perlapine Pipebuzone Pirenzepine Prochlorperazine Rufloxacin hydrochloride Sildenafil Tiotixene... [Pg.2420]

QH2F3NO2 771-69-7) see Levofloxacin Ofloxacin Rufloxacin hydrochloride 2,3>4-trihydroxybenzaldebyde (C7H(,04, 2144-08-3) see Benserazide... [Pg.2450]

Eurlanetto, S., Orlandini, S., La Porta, E., Coran, S., and Pinzauti, S. (2002). Optimization and validation of a CZE method for rufloxacin hydrochloride determination in coated tablets.. Pharm. Biomed. Anal. 28(6), 1161-1171. [Pg.168]

See other pages where Rufloxacin is mentioned: [Pg.863]    [Pg.225]    [Pg.292]    [Pg.298]    [Pg.1843]    [Pg.1843]    [Pg.1844]    [Pg.1844]    [Pg.2328]    [Pg.2329]    [Pg.2329]    [Pg.2342]    [Pg.2347]    [Pg.2351]    [Pg.2351]    [Pg.2352]    [Pg.2352]    [Pg.2377]    [Pg.2378]    [Pg.2384]    [Pg.2385]    [Pg.2385]    [Pg.2386]    [Pg.2443]    [Pg.2446]    [Pg.117]    [Pg.118]    [Pg.119]    [Pg.120]    [Pg.134]    [Pg.141]    [Pg.150]    [Pg.162]    [Pg.597]    [Pg.603]    [Pg.598]    [Pg.605]    [Pg.813]    [Pg.279]    [Pg.150]    [Pg.216]   
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See also in sourсe #XX -- [ Pg.279 ]

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See also in sourсe #XX -- [ Pg.84 , Pg.225 ]

See also in sourсe #XX -- [ Pg.320 ]

See also in sourсe #XX -- [ Pg.84 , Pg.225 ]

See also in sourсe #XX -- [ Pg.84 , Pg.225 ]

See also in sourсe #XX -- [ Pg.40 ]



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