Route Design and Process Optimization to Minimize COG

The CIAT and CIDR processes should be considered when appropriate before Phase 2 in order to decrease the cost of labor and raw materials for large amounts of materials. If a CIAT or CIDR process is identified earlier, it may be wise to devote time and resources to develop and exploit it. The potential for CIAT and CIDR processes may be uncovered by simply extending and carefully monitoring processes in the laboratory. 

Art is elegance in simplicity for scale-up operations. Many of the examples shown have resulted in simplified processes through detailed investigations and thorough process development. Simplified processes that control the key parameters are the most reliable for scale-up operations. 

Anderson, N. G. (2000). Practical Process Research Development, Academic Press, San Diego. 

Blaser, H. U. and Schmidt, E., (Eds) (2004). Asymmetric Catalysis on Industrial Scale, Wiley-VCH, Weinheim. 

and Di Fahio, R. (2000). From Bench to Market The Evolution of Chemical Synthesis, Oxford University Press, New York. 

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