Selegiline Ropinirole

ROPINIROLE, SELEGILINE OESTROGENS t levels of ropinirole and selegiline Inhibition of metabolism (possibly /V-demethylation) Watch for early features of toxicity (nausea, drowsiness) when starting oestrogens in a patient stabilized on these dopaminergics. Conversely, watch for poor response to them if oestrogens are stopped... 

Great caution must be exercised in the use of this drug (or drugs from the same class) in parkinsonian patients who have prostatic hypertrophy or obstructive gastrointestinal disease (A) Benztropine Carbidopa Levodopa Ropinirole Selegiline... 

A large number of molecules have provided experimental evidence of neuroprotection in in vitro and in vivo models of Parkinson s disease and many of these putative neuroprotective substances are now the objects of clinical trials. Recently, a team of experts has identified potential neuroprotective agents to be tested in pilot studies [4]. Twelve compounds have been considered for clinical trials caffeine, coenzyme Q 10, creatine, estrogen, GPI1485, GM-1 ganglioside, minocycline, nicotine, pramipexole, ropinirol, rasagiline, and selegiline (for individual discussion see [4]). 

DA agonists levodopa, bromocriptine, ropinirole, pramipexole, selegiline... 

Drugs used to increase DA fundion are levodopa, tolcapone, entacapone, bromocriptine, pramipexole, ropinirole, and selegiline. Drugs that decrease ACh fundion are benztropine, trihexyphenidyl, and amantadine. The properties of each are described. 

DA agonists levodopa, bromocriptine, ropinirole, pramipexole, selegiline AAAD inhibitor carbidopa M-blockers benztropine, trihexiphenidyl MAOIs phenelzine, tranylcypromine TCAs amitriptyline, imipramine, clomipramine SSRIs fluoxetine, paroxetine, sertraline Others bupropion, mirtazapine, nefazodone, trazodone... 

Another strategy is to directly enhance dopamine function as well as the activities of B-cell lymphoma protein 2 (Bcl-2), which is another important component that may play a role, eventually, in the resolution of depression. Examples of various non-selective enhancers of dopamine that also stimulate Bcl-2 are pergolide, ropinirole, and selegiline, while pramipexole may directly enhance Bcl-2. The antidepressant effect exhibited by enhanced dopaminergic transmission is thought to be at least partially related to increased dopaminergic transmission in limbic structures (e.g. the nucleus accumbens). - ... 

No significant pharmacokinetic interaction occurs between selegiline and cabei oline, pramipexole or ropinirole. 

The manufacturers of ropinirole note that a population pharmacokinetic analysis showed a lack of effect of selegiline on ropinirole. ... 

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