Roles of Templates

I would like to thank my students who have played a crucial part in the rapid progress that we have made on the role of template-mediated synthesis of hemozoin. I would also like to thank Professor D. Scott Bohle for providing a preprint of the most recent powder diffraction model of hemozoin and for reading sections of this manuscript prior to submission. Without his assistance and cooperation, this review would have been instantly out of date. I would also like to thank the Research Corporation, the Hunkele Charitable Trust of Pittsburgh, the National Foundation of Infectious Diseases, and Duquesne University for financial support of this work. 

L. E. Scriven Yes, I had zeolites in mind, not as catalysts themselves but because of the role of templates in the synthesis of zeolites, templates that catalyze the desired supramolecular structure. That would serve as a point of discussion on this notion. 

Davidson (2002) Mesoporous silica Structure evolution, role of templates crystallization variables + + n.a. Synthesis of mesoporous silica with defined properties... 

These results represent the most spectacular example of the dramatic role of template effects as the main factors affecting the assemblage of complex three-dimensional structures with a high degree of pre-organization in the multi-component reaction complex. 

The role of template-template self-association in molecular imprinting was the subject of extensive debate during the early work with silica-based systems [1]. Its involvement in organic polymer imprinting has, however, attracted much less... 

We can go beyond the case of fast-ion conductors and apply these principles to understand the role of templating species in inorganic and organic synthesis. A number of examples of zeolite frameworks have been shown in Chapter 2 to follow closely IPMS. The crystallisation of zeolites invariably requires the presence of templating species. A wide variety of templates have been used, from sodium ions, tetra-alkyl ammonium ions to crown ethers. 

Studies on the roles of templates or SDAs in the synthesis of microporous compounds have always attracted the attention of chemists in this held. Choosing an appropriate SDA for a specific framework is the key issue in the synthesis of new microporous structures. 

Templaied synthesis plays a central role in any discussion about the emergence of life. This is because it was certainly involved in two stages of the evolution of life— self-replication and translation (protein synthesis) — and possibly in the third, polymerization of monomers or shorter oligomers of amino acids and nucleotides into peptides and (longer) oligonucleotides. The role of templated synthesis in supramolecular chemistry is ubiquitous and well documented. Before going further, it is... 

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