Role of Hyaluronic Acid in Fertilization

Simultaneously, the probabihty of egg fertilization is reduced. In humans, fertiUty of the egg cell is preserved for a period of 12-24h after ovulation and complete uncovering of the oocyte occurs after 30 h. Hyaluronan and other glycosaminoglycans of zona pellucida and corona radiata prevent the egg from adhering to the wall of fallopian tube, thus reducing the risk of ectopic pregnancy. It has been experimentally demonstrated that retardation of HA breakdown in the intercellular matrix leads to inhibition of folUcular cells apoptosis and preservation of egg fertility [46]. For the fertilization to take place, that is, introduction 

Maintenance of normai water balance, skin hydration, moisture retention, improvement of tone, eiasticity, microcircuiation and rate of skin regeneration. 

Penetrate transepidermai barrier, stimulate growth of blood and lymphatic capillaries, improves microcirculation and the nourishment of the skin. 

Possess the wound healing properties, stimulate proliferation of cells and their migration into wounds. 

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