Dominant Lethal Test Rodent

Genetic Toxicology Rodent Dominant Lethal Test (Updated Guideline, adopted 4 April 1984)... 

Genetic toxicology Rodent dominant lethal test... 

B.ll Mutagenicity - In vivo mammalian bone-marrow chromosome aberration test B.12 Mutagenicity mammalian erythrocyte micronucleus test B.20 Sex-Unked recessive lethal test in Drosophila melanogaster B.22 Rodent dominant lethal test... 

The rodent dominant lethal test OECD TG 478 US-EPA OPPTS 870.5450 EU Annex V B.22... 

A positive response in the rodent dominant lethal test indicates that the test substance may be genotoxic in the germ cells of the treated sex of the test species as evaluated by an increase in the number of dominant lethals evaluated as the sum of pre- and postimplantation loss. A dominant lethal mutation is one occurring in a germ cell, which does not cause dysfunction of the gamete but which is lethal to the fertilized egg or developing embryo. 

Stodddard solvent was not genotoxic in a variety of assays including Salmonella typhimurium, a mouse lymphoma mutation assay, rodent bone marrow cytogenic tests, and rodent dominant lethal tests." ... 

OECD (1984). Genetic toxicology Rodent dominant lethal test. OECD Guideline for the Testing of Chemicals 478, 1-6. 

Rodent-dominant lethal test Germinal tissue of rodent Chromosome aberrations and/or gene mutations in germinal tissue B22/TG 478... 

Ethylene dibromide is mutagenic in bacteria and Drosophila, and in rodent and human cells in vitro. It induced DNA breakage but not chromosomal aberrations or micronuclei in vivo in rodents. It gave negative results in dominant lethal tests in mice and rats. It did not induce either chromosomal aberrations or sister chromatid exchange in humans in vivo. 

Dominant-lethal test (DLT test) in rodents to detect heritable translocations... 

OPPTS Harmonized/870 Health Effects Test G uidelines/Series/870-6300.pdf EPA (U.S. Environmental Protection Agency). 1998d. Health Effects Test Guidelines OPPTS 870.5450 Rodent Dominant Lethal Assay. EPA 712-C-98-227. Office of Prevention, Pesticides and Toxic Substances, U.S. Environmental Protection Agency. [Online]. 

Rodent dominant lethal mutation test (OECD 478)... 

Mouse visible or eleetrophoretie specifie-locus tests Assays for skeletal and cataract mutations Cytogenetic analy.sis and heritable translocation assays DNA damage and repair in rodent germ cells Dominant lethal assay... 

Laboratory experiments using rodents, or the use of gas analysis, tend to be confused by the dominant variable of fuel—air ratio as well as important effects of burning configuration, heat input, equipment design, and toxicity criteria used, ie, death vs incapacitation, time to death, lethal concentration, etc (154,155). Some comparisons of polyurethane foam combustion toxicity with and without phosphoms flame retardants show no consistent positive or negative effect. Moreover, data from small-scale tests have doubtful relevance to real fine ha2ards. 

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