Rockefeller Institute for Medical Research

Experimental Medicine in St. Petersburg in 1890, and the Kitasato Institute in Tokyo in 1892-3, commemorating von Behring s discovery, with Kitsato, of diphtheria antitoxin. In New York, the Rockefeller Institute for Medical Research was incorporated in 1901 and in London the Lister Institute for Medical Research was established by 1903. 

From the Laboratories of the Rockefeller Institute for Medical Research, New York)... 

More attention began to be paid to nucleic acids in 1945 when Oswald Avery of the Rockefeller Institute for Medical Research found that he could cause a nonvirulent The bacterium was strepto- strain of bacterium to produce virulent offspring by incubating them with a substance... 

They are indebted to Alec G. Bearn, Rockefeller Institute for Medical Research, for collaboration in preliminary studies and for valuable discussion of the problems in ceruloplasmin metabolism. 

The writer is indebted to Dr F A. Taylor of the Rockefeller Institute for Medical Research for placing at his disposal the results of working over the method of Fischer and Dllthey, Awn. 335, 338 (1904). 

Cf. Behrend, Ann 353, 106 (1907). Thanks are due Dr. G. M Meyer of the Rockefeller Institute for Medical Research for several improvements on the original methods in this and section B. 

Acknowledgment is due Dr L. A. Mikeska of the Rockefeller Institute for Medical Research for details of this method and of slight modifications of Fischer s procedure in the following preparations. 

Acknowledgment is gratefully made to Dr. Lillian E. Baker of the Rockefeller Institute for Medical Research for the use of her notes on this preparation. Hopkins original method, modified in several details, and made more precise, was found to give crystalline preparations more consistently than Soerensen 3 modification. 

Merrifield A process for synthesizing peptides, using a solid phase support. The basic process was invented in 1962 by R.B. Merrifield at the Rockefeller Institute for Medical Research, New York, and it was subsequendy automated with the assistance of J. Stewart. The solid supports are chloromethylated copolymers of styrene with divinyl benzene, now commercially available. The process is now widely used commercially for making therapeutic medicines. Merrifield received the Nobel Prize for this work in 1984, which he chose not to patent. 

Recent investigatioins at the National Heart Institute, Bethesda, Maryland, and the Rockefeller Institute for Medical Research, New York, indicate that the sequence of ribonuclease involving residues 11 through 18 is incorrect as shown in Fig. 17. The correct sequence will be published shortly by both of the laboratories (personal communication from C. B. Anfinsen). 

Fig. 19. Topography of the NBS cleavage of the six tyrosyl peptide links of native and

Dr. Lyman C. Craig, Rockefeller Institute for Medical Research New York. N. Y. U. S. A. 

Dam conducted research at Woods Hole Marine Biological Laboratories during the summer and autumn of 1941 and at the University of Rochester, N.Y., where he served as a senior research associate between 1942 and 1945. He was at the Rockefeller Institute for Medical Research in 1945 as an associate member. 

ASSOCIATE MEMBER THE ROCKEFELLER INSTITUTE FOR MEDICAL RESEARCH... 

Though both discoverers deserve recognition, Menten faced the additional challenge of being a woman scientist at a time when professional advancement for women was very difficult. Bom in Port Lambton, Ontario, Canada, Menten graduated from the University of Toronto with a B.A. in 1904 and an M.B. in medicine in 1907. For the 1907 to 1908 year, she was appointed a fellow at the Rockefeller Institute for Medical Research, New York, where she studied the effect of radium on tumors. Returning to Canada, Menten continued her medical studies, and in 1911 she became one of the first women in Canada to receive a medical doctorate. 

After a few months in Washington, Wolfrom moved in September, 1927, to New York City in order to work in the laboratory of P. A. Levene at the Rockefeller Institute for Medical Research. Levene, the outstanding master on the North American continent in the young discipline of biochemistry, was an ardent genius with a remarkable capacity for hard work, an urbane and cosmopolitan personality, and a warm interest in all of those who worked with him. In his contact with Levene, Wolfrom was able to assimilate at firsthand some of the valuable aspects of the European traditions in science that Levene was able to convey to his coworkers at the Rockefeller Institute, and he was simultaneously exposed to the enormous challenge to the structural chemist offered by the seemingly hopeless slimes and mucins that... 

The fact that 20-50 percent of the bacteria in soil are effective in destroying a variety of microorganisms, including other bacteria, has been known for many decades. In 1939 this prompted Rene Dubos (1901-82), at the Rockefeller Institute for Medical Research, to examine one such bacterium. Bacillus brevis, firom which he isolated a chemical component, tyrothricin, capable of destroying bacteria. The cyclic decapeptide gramicidin S, sequenced by Martin and Synge, is derived from tyrothricin. 

---