Risperidone sexual function

Knegtering R, Castelein S, Bous H, van der Linde J, Bruggeman R, Kluiter H, van den Bosch RJ. A randomized open-label study of the impact of quetiapine versus risperidone on sexual functioning. J Clin Psychopharmacol 2004 24 56-61. 

Endocrine Aripiprazole is said to stabilize the dopaminergic system and thus ameliorate schizophrenic symptoms without increasing serum prolactin [SEDA-31, 76]. Prolactin concentrations and sexual function in schizophrenic patients have been evaluated in an open, 26-week, multicenter study, in which 555 patients were randomized to aripiprazole ( = 284) or standard care (olanzapine, quetiapme, or risperidone n = 271) [69 ]. At 8 weeks, those who took aripiprazole reported significantly greater improvement in sexual function. Baseline mean serum prolactin concentrations were similar in the two groups (434 and 423 mg/1 respectively) however, at week 26, the mean fall in serum prolactin was 342 mg/1 with aripiprazole compared with 133 mg/1 with the other treatments. 

Sexual function A study of 100 men with psychotic disorders found that the rate of sexual dysfunction was highest for risperidone, followed by trifluoperazine and olanzapine, measured on three different scales [73 ]. Rates of sexual function varied according to the scale used decreased libido was the most prevalent except for orgasmic disorders for risperidone on the ASEX scale. 

Sexual function A 3-month, open-label study evaluating a switch from risperidone microspheres to paliperidone palmitate reported a significant decrease in serum prolactin levels and a fourfold reduction in sexual dysfunction measure on the Arizona Sexual Experience Scale [197 j. 

Sexual Function Hypersexuality secondary to the use of risperidone in three patients with schizophrenia is thought to be associated with risperidone s antagonism of 5-HT2A and alpha-2 adrenergic antagonism [265 ]. 

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