Ring immune responses

Deep corneal edema with folds in Descemet s membrane, in the presence of an intact epithelium, can develop from 3 to 4 months after acute HZO. This disciform keratitis may involve the full thickness of the cornea and may be surrounded by a ring-like cellular infiltrate called a Wessley ring. It is considered to be an immune response to viral antigens and responds quickly to topical steroids, especially when initiated early. Unfortunately, it is common to have recurrences when steroids are tapered or discontinued and can lead to corneal scarring or, more seriously, corneal melt.There is often an associated anterior uveitis with keratic precipitates as well as diffuse corneal edema, endothelial cell loss, and increased lOP secondary to trabeculitis. 

The imidazole molecule is incorporated into many biologically relevant molecules. For example, the amino acid histidine is present in proteins and enzymes, while histamine (its decarboxylated product) is important in the body s immune response system. The imidazole ring has been found in a number of natural products, particularly the oroidin-derived alkaloids. One of the structurally simple compounds in this class of natural products is girolline, containing a 2-amino-imidazole attached to a chlorohydrin moiety. ... 

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