Rifampicin digoxin

RIFAMPICIN DIGOXIN Plasma concentrations of digoxin may be 1 by rifampicin Rifampicin seems to induce P-gp-mediated excretion of digoxin in the kidneys Watch for l response to digoxin, check plasma levels and t dose as necessaiy... 

Drug Interactions Gemfibrozil Niacin Erythromycin Cholestyramine Digoxin Cimetidine/ranitidine/ omeprazole Rifampicin Warfarin Itraconazole Gemfibrozil Niacin Erythromycin Propranolol Digoxin Warfarin Antacids Colestipol Digoxin Erythromycin Oral contraceptives Fibrates Niacin Azole antifungals... 

Figure 10 Effect of repeated administration of rifampicin on the time profile of the plasma concentration of digoxin following intravenous and oral administration. Eight healthy male volunteers [age 29 5 years, body weight 84 9 kg (mean SD)] were included in the study. Plasma concentration (mean SD) time curves of digoxin given orally (1 mg) (A) and intravenous infusion over 30 minutes (1 mg) (B) before open circles) and during (filled circles, day 11) coadministration of rifampicin (600 mg, once daily orally for 16 days). Source From Ref. 372.

Table 2 Effect of Rifampicin (600 mg/day for 10 days) on the Absorption Kinetics of Digoxin (1 mg PO) in Healthy Volunteers...

Drugs digoxin, methotrexate (25 iM), ouabain, fluvastatin, rosuvastatin, rifampicin (2pM), bosentan, Ro 48-5033, Eluo-3 (6.8 pM)... 

Oat2 Benzylpenicillin, erythromycin, tetracycline, rifampicin, glibenclamide, tolbutamide, zidovudine, ganciclovir, digoxin, enalapril, verapamil, methotrexate, acetylsalicylic add... 

Figure 12.4 Influence of rifampicin and quinidine on concentrations of Dg2 in perfusate after addition of 10 ug of digoxin to the perfusate. Values are mean SD, n = 6 per group no liver, n = 3. p<0.05 fxO.Ol for values com pared to control. From Ref. [29].

Cronqvist, J. Nilsson-Ehle, I. Determination of acyclovir in human serum hy hi -performance liquid chromatography. J.Liq.Chromatogr., 1988, 11, 2593-2601 [serum non-interfering acetaminophen, allopurinol, baclofen, carbacholine, cefuroxime, chlorpropamide, cilastatin, cloxacillin, diazepam, di-cumarol, digoxin, flucloxacillm, furosemide, fusidic acid, fusidic, glipizide, heparin, hydrochlorothiazide, imipenem, insulin, isoniazid, ketoprofen, metronidazole, naproxen, perphenazine, phenytoin, prednisolone, propranolol, p3razinamide, p3ridoxine, ranitidine, rifampicin, rifampin, spironolactone, streptomycin, sulfamethoxazole, trimethoprim, warfarin]... 

A 60-year-old woman taking digoxin, furosemide and warfarin (ESTR 3.5 to 5) developed a fever after mitral valve replacement surgery and was given rifampicin 450 mg twice daily and teicoplanin 400 mg twice daily. Within 3 days her ESTR began to fall and by day 6 the anticoagulant effect was completely lost. Despite progressive warfarin increases to 10, 15, and then 20 mg daily, her INR stayed between 1.2 and 1.6, even when the rifampicin was stopped, and remained low for a further 20 days, at whieh point the teicoplanin was also stopped. ... 

The serum levels of digitoxin can be halved by rifampicin (rifampin). Digoxin serum levels are modestly reduced by rifampicin. 

A woman, hospitalised for endocarditis, taking digoxin 250 to 375 micrograms daily, furosemide, aspirin, isosorbide dinitrate and potassium chloride, had a marked fall of about 80% in her serum digoxin level when she was given rifampicin 600 mg daily. The serum digoxin returned to its former level over the 2 weeks following rifampicin withdrawal. She had only moderate renal impairment (serum creatinine 221 micromol/L). 

Another report describes 2 patients undergoing renal dialysis whose digoxin dosage needed to be doubled while they were taking rifampicin, and similarly reduced when the rifampicin was withdrawn. This confirms an earlier report. ... 

A study in 8 healthy subjects foimd that the AUC and maximum plasma levels of a single 1-mg oral dose of digoxin were reduced hy 30% and 52%, respectively, by rifampicin 600 mg daily for 10 days. In two further studies in which rifampicin 300 mg twice daily for 7 days was used as a positive control, the AUC of a single oral dose of digoxin was reduced by 16%, and the maximum levels were reduced by about 25%. ... 

Deferasirox did not alter the pharmacokinetics of digoxin. Food increases the bioavailability of deferasirox, and it should be taken on an empty stomach. The use of deferasirox with aluminium antacids is not recommended. Rifampicin, phenobarbital and pheny-toin are predicted to increase the metabolism of deferasirox, and, until more is known, concurrent use should be monitored. Based on in vitro data, deferasirox might inhibit the metabolism of CYP2C8 substrates like paclitaxel and repaglinide. Hydroxycar-bamide does not alter deferasirox metabolism. 

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