Rheumatoid arthritis predisposing factors

What are the predisposing factors associated with rheumatoid arthritis ... 

Gomez-Reino JJ, CarmonaL, Valverde VR, et al. Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk A multicenter active-surveillance report. Arthritis Rheum 2003 48 2122-2127. 

Trauma also appears to be a risk factor in facilitating microorganism entry into the synovial space. One study found that 35% of patients with infectious arthritis had preexisting joint disease. Unlike children, adults often have significant systemic diseases that predispose them to infectious arthritis, such as diabetes meUims, immunosuppressive states (cancer, fiver disease), or preexisting arthritis. Intravenous drug abusers also are prone to develop septic arthritis. Arthritis, joint trauma, and surgery are other important risk factors because chronic inflammation or trauma makes the joint more susceptible to infection. In addition, rheumatoid arthritis patients may be prone to... 

The development of the intestinal microbiota needs to be characterized to define the composition that helps us to remain healthy. Specific aberrations in the intestinal microflora may predispose to disease. Such aberrations have been identified in allergic disease, including decreased numbers of bifidobacteria and an atypical composition of bifidobacterial microflora. Also, aberrations in Clostridium content and composition have been reported to be important. Similar predisposing factors may also exist in the case of microflora and both inflammatory gut diseases and rotavirus diarrhea. Microflora aberrations have also been reported in rheumatoid arthritis, juvenile chronic arthritis, ankylosing spondylitis, and irritable bowel syndrome patients. A thorough knowledge of the intestinal microflora composition will offer a basis for future probiotic development and the search for new strains for human use. Many diseases and their prevention can be linked to the microflora in the gut. 

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