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Rheumatoid arthritis genetics

In most Caucasian populations with rheumatoid arthritis, genetic susceptibility is conferred by HLA-DRB1 alleles that share a common amino acid sequence ( shared epitope ) in the third hypervariable region of the HLA-DRB 1 chain (amino acids 70-74 QRRAA, QKRAA, RRRAA) (Gregersen et al., 1987 Nepom,... [Pg.33]

Soluble receptor constructs Etanercept This genetically engineered drug consists of the extracellular-part of the TNF-receptor type I and the Fc portion of human IgG. Its application in rheumatoid arthritis mirrors that of infliximab. [Pg.617]

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown aetiology with some autoimmune features. Current thinking favours the hypothesis that interplay between genetic factors, sex hormones, and possibly an infectious agent or another immune activating agent initiates an autoimmune pathogenic mechanism that culminates in a disease with inflammatory and destructive features. [Pg.1080]

Corominas, H., Domenech, M., Laiz, A., et al. (2003) Is thiopuiine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients Rheumatology. 42, 40-45. [Pg.434]

Gregersen, P. K., Silver, J., and Winchester, R.J. (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis and Rheumatism. 30, 1205-1213. [Pg.436]

Mulcahy, B., Waldron-Lynch, F., McDermott, M. F., et al. (1996) Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis. American Journal of Human Genetics. 59, 676-683. [Pg.436]

Gene therapy holds great promise for the treatment of many diseases (e.g., cancer, AIDS, cystic fibrosis, adenosine deaminase deficiency, cardiovascular diseases, Gaucher disease, a 1-antitrypsin deficiency, rheumatoid arthritis, and several others) (1,2). Advances in genomics and molecular biology have revealed that almost all diseases have a genetic component. In some cases, such as cystic fibrosis or hemophilia,... [Pg.333]

Etanercept is a genetically engineered protein that is soluble TNF-a receptor. Its molecular weight is 75kDa. It binds to TNF-a. It is used for the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Structurally, two TNF-a receptors are linked to an Fc portion of an... [Pg.51]

Payami H, Thomson G, Khan MA, Grennan DM, Sanders P, Dyer P, Dostal C. Genetics of rheumatoid arthritis. Tissue Antigens 1986 27 57-63. [Pg.581]

Silman AJ, Pearson JE. Epidemiology and genetics of rheumatoid arthritis. Arthritis Res 2002 4(suppl 3) S265-S272. [Pg.606]

Horrobin, D.F., Low prevalences of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic... [Pg.338]

See other pages where Rheumatoid arthritis genetics is mentioned: [Pg.2556]    [Pg.2556]    [Pg.146]    [Pg.535]    [Pg.155]    [Pg.7]    [Pg.365]    [Pg.84]    [Pg.432]    [Pg.499]    [Pg.559]    [Pg.574]    [Pg.16]    [Pg.433]    [Pg.436]    [Pg.320]    [Pg.13]    [Pg.13]    [Pg.59]    [Pg.74]    [Pg.10]    [Pg.543]    [Pg.1188]    [Pg.158]    [Pg.220]    [Pg.64]    [Pg.218]    [Pg.226]    [Pg.268]    [Pg.133]    [Pg.1335]    [Pg.97]    [Pg.139]    [Pg.390]    [Pg.470]    [Pg.557]    [Pg.590]    [Pg.591]    [Pg.608]   
See also in sourсe #XX -- [ Pg.151 ]



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