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New Drugs by Genetic Engineering

Approaches to produce new compounds with altered structures involved targeted gene disruption experiments, expression of single genes or gene clusters, and the rational design. In this chapter, we summarize the currently available strategies to create novel molecules. [Pg.382]

Genetic engineering and its associated disciplines, as first developed in bacteria, have already made major impacts in the world of medicine and finance and are changing the face of agriculture and industry today and will continue to do so. Bacteria have been employed to produce many mammalian polypeptides as pharmaceuticals of major importance to modern medicine (Demain and Vaishnav 2009). The improvement of secondary metabolite production processes and the discovery of new drugs (by combinatorial biosynthesis) can be attributed to the remarkable developments of recombinant DNA technology (Ferrer-Miralles et al. 2009). [Pg.277]

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