Reversible injury

Reversible injury or irreversible injury or death Carcinogens... 

LDso in rabbits was 1.3 g/kg. It was moderately to severely irritating to rabbit skin. The liquid tested in the eye caused mild reversible injury. 

Toxicity Any acute exposure to vapors of 1,1,1-trichloroethane leads to irritation of the nose, throat, and eyes, and results in headaches. Exposure to high concentrations or vapors of 1,1,1-trichloroethane is known to cause damage to the CNS, leading to behavioral disorders, dizzy spells, sleepiness, and, in some cases, coma reversible injuries to the liver and kidneys also have been observed. Overexposure of 1,1,1-trichloroethane in occupational/work environments causes headache, CNS depression, irritation to eyes, dermatitis, and cardiac arrhythmias. Effects of repeated or long-term exposure to the solvent causes visual problems, loss of coordination, reduction of the tactile sensitivity of the skin, trembling, giddiness, anxiety, and slowing of the pulse rate. 

Currently, the precise biochemical events initiating irreversible cell injury are unknown. At what stage did the cell actually die What is the critical biochemical event responsible for the point of no return There is no universally accepted biochemical explanation for the transition from reversible injury to cell death. The duration of hypoxia necessary to induce irreversible cell injury varies according to cell type and its nutritional and hormonal status ... 

Hepatic Steatosis/Fatty Liver Hepatic steatosis is the accumulation of fat droplets within the hepatocytes. Steatosis is usually a common response noted with a variety of liver toxicants and represents a potentially reversible injury to hepatocytes (Treinen-Moslen, 2001). Grossly, the affected liver will be swollen with rounded edges, friable, and light brown to yellow in color. Compounds that produce prominent steatosis include... 

SLIGHT Irritation or minor reversible injury possible. Materials (hat must be preheated before ignition will occur. Flammable liquids in this category will have flash points (the lowest temperature at which ignition will occur) at or above 200 F (93 C) (NFPA Class IflB). Materials that are normally stable but can become unstable at high temperatures and pressures. These materials may react with water but they will not release energy violently. 

B. Mainly contact with chemicals classified as toxic, harmful or irritant. Intermediate risk for moderate, reversible injuries. 

Chloroform Central nervous system depression toxic to liver and kidneys classified as probable human carcinogen. Repeated or prolonged exposure causes irritation and defatting. High vapor concentrations cause conjunctivitis and spasmodic winking contact with liquid causes a burning sensation and reversible injury to the corneal epithelium. 

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