Retinol-binding protein amino acid sequence

Figure S.S Amino acid sequence of p strands 2 3 4 in human plasma retinol-binding protein. The sequences are listed in such a way that residues which point into the barrel are aligned. These hydrophobic residues are arrowed and colored green. The remaining residues are exposed to the solvent.

There is a second family of small lipid-binding proteins, the P2 family, which include among others cellular retinol- and fatty acid-binding proteins as well as a protein, P2, from myelin in the peripheral nervous system. However, members of this second family have ten antiparallel p strands in their barrels compared with the eight strands found in the barrels of the RBP superfamily. Members of the P2 family show no amino acid sequence homology to members of the RBP superfamily. Nevertheless, their three-dimensional structures have similar architecture and topology, being up-and-down P barrels. 

Berni, R., M. Stoppini and M.C. Zapponi. The piscine plasma retinol-binding protein. Purification, partial amino acid sequence and interaction with mammalian transthyretin. Eur. J. Biochem. 204 99-106, 1992. 

Amino Terminal Amino Acid Sequences of Cellular Retinol-Binding (CRBP) Protein from Various Species"... 

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