Retinoid X receptor alpha

Pascussi JM, Drocourt L, Fabre JM, Maurel P, Vilarem MJ (2000a) Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepa-tocytes synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol 58, 361-372. 

Cristiano, F., Bernardo, A., and Ceru, M. P. (2001). Peroxisome proliferator-activated receptors (PPARs) and peroxisomes in rat cortical and cerebellar astrocytes. J. Neurocytol. 30, 671—683. Cullingford, T. E., Bhakoo, K., Peuchen, S., Dolphin, C. T., Patel, R., and Clark, J. B. (1998). Distribution of mRNAs encoding the peroxisome proliferator-activated receptor alpha, beta, and gamma and the retinoid X receptor alpha, beta, and gamma in rat central nervous system. J. Neurochem. 70, 1366-1375. 

Dilworth FJ, Fromental-Ramain C, Rem-boutsika E, Benecke A, Chambon P. 1999. Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha and retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo. Proc. Natl. Acad. Sci. USA 96 1995-2000... 

Lee MS, Kliewer SA, Provencal J, et al. Structure of the retinoid X receptor alpha DNA binding domain A helix required for homodimeric DNA binding. Science. 1993 260 1117-21. 

Palmer, C.N., M.H. Hsu, A.S. Muerhoff, K.J. Griffin and E.F. Johnson. Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1 binding site in the CYP4A6 promoter. J. Biol. Chem. 269 18083-18089, 1994. 

Vanden Heuvel, J. P., Thompson, J. T., Frame, S. R., and Gillies, P. J. (2006). Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. Toxicol Sci 92, 476-489. 

Auerbach, S. S., Stoner, M. A., Su, S., and Omiecinski, C. J. (2005) Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Mol. Pharmacol. 68, 1239-1253. 

Dexamethasone Induces Pregnane X Receptor and Retinoid X Receptor-Alpha Expression in Human Hepatocytes Synergistic Increase of CYP3A4 Induction by Pregnane X Receptor Activators. 

Retinoids (i.e., tretinoin and tazarotene) mediate cellular responses primarily through activation of nuclear retinoid receptors [rr]. There are two types of nuclear retinoic acid receptors the retinoic acid receptors (RARs) and the retinoid X receptors. Each type of receptor contains three receptor subtypes alpha, beta, and gamma [rr, 11]. Among the commonly prescribed retinoids, tretinoin activates the RARs alpha, beta, and gamma directly, and the retinoid X receptors indirectly (through conversion of tretinoin to 9-cis-retinoic acid) [rr, 13]. Conversely,... 

B. Roy, R Taneja, and P. Chambon. Synergistic activation of retmoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor alpha (RAR alpha)-, RAR beta-, or RAR gamma-selective ligand in combination with a retinoid X receptor-specific ligand. Mol Cell Bid, 15 (12), 6481-6487, 1995. 

Xu J, Storer PD, Chavis JA, Racke MK, Drew PD (2005) Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia. J Neurosci Res 81 403 11. 

Fig. 6. Coordinated transcriptional regulation of fatty acid desaturases and elongases in mammals. PUFA, polyunsaturated fatty acids +, stimulation inhibition LXR, liver X receptor RXR retinoid X receptor SREBP, sterol regulatory element binding protein ChREBP, carbohydrate response element binding protein Mix, Max-like receptor PPAR-ot, peroxisome proliferator activated receptor alpha LXRE, liver X receptor response element SRE, sterol response element ChoRE, carbohydrate response element PPRE, peroxisome proliferator response element. (See color plate section, plate no. 6.)...

Steineger, H.H., Amtsen, B.M., Spydevol4 O. Sorensen, H.N. 991)Biochimiel9, 107-110. Retinoid X receptor (RXR alpha) gene expression is regulated by fatty acids and dexamethasone in hepatic cells. 

Steineger, H.H., Arntsen, B.M., Spydevold, 0. Sorensen, H.N. (1997) BiochimieT9, 107-110. Retinoid X receptor (RXR alpha) gene expression is regulated by fatty acids and dexamethasone in hepatic cells. Dallman, M.F., Strack, A.M., Akana, S.F., Bradbury, MJ., Hanson, ES., Scribner, K.A. Smith, M. (1993) Front. Neuroendocrinol. 14, 303-347. Feast and famine critical role of glucocorticoids with insulin in daily energy flow. 

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