Retinoic acid metabolism

Patel, J. B., J. Mehta et al. (2007). Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br. J. Cancer 96(8) 1204—1215. [Pg.413]

A striking feature of the collection of human brain cytochrome P450s discussed in the present review is the obvious major classes they fall into. With the exception of CYP26A1, which appears to be alone in the retinoic acid metabolic pathway, all the other brain P450s, including those normally considered xenobiotic-metabolizing, are either involved in the metabolism (or synthesis, in the case of CYP51, the... [Pg.65]

Emoto Y, Wada H, Okamoto H, Kudo A, Imai Y. 2005. Retinoic acid-metabolizing enzyme Cyp26al is essential for determining territories of hindbrain and spinal cord in zebrafish. Dev Biol 278 415-427. [Pg.83]

White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, et al. 1997. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. J Biol Chem 272 18538-18541. [Pg.90]

White JA, Ramshaw H, Taimi M, Stangle W, Zhang A, et al. 2000. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. Proc Natl Acad Sci USA 97 6403-6408. [Pg.92]

BlanerWS, Olson JA Retinol and retinoic acid metabolism, in Sporn MB, Roberts AB, Goodman DS (eds) The Retinoids Biology, Chemistry, and Medicine. 2nd ed. Raven Press, New York, 1994, pp. 229-256. [Pg.322]

Andreola F, Fernandez-Salguero PM, Chiantore MV, Petkovich MP, Gonzalez FJ, De Luca LM. 1997. Aryl hydrocarbon receptor knockout mice (AHR—/—) exhibit liver retinoid accumulation and reduced retinoic acid metabolism. Cancer Res. 57 2835-38... [Pg.332]

Marrih J, Idres N, Capron CC, et al. Retinoic acid metabolism and mechanism of action a review, Curr Drug Metab 2003 93 284-9. [Pg.1155]

Freyne, E., Raeymaekers, A., Venet, M., Sanz, G., Wouters, W., De Coster, R. and Wauwe, J.V. (1998) Synthesis of LIAZAL, a retinoic acid metabolism blocking agent (RAMBA) with potential clinical applications in oncology and dermatology. Bioorganic at Medicinal Chemistry Letters, 8, 267-272. [Pg.406]

Van Wauwe, J., Van Nyen, G., Coene, M.C., Stoppie, P., Cools, W., Goossens, J., Borghgraef, P. and Janssen, P.A. (1992) Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo. The Journal of Pharmacology and Experimental Therapeutics,... [Pg.406]

Abu-Abed, S., Dolle, P., Metzger, D., Beckett, B., Chambon, P., Petkovich, M. 2001. The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev. 15, 226-240. [Pg.194]

Schwartz, E.L. Hallam, S. Gallagher, R.E. Wiernik, P.H. Inhibition of all-trans-retinoic acid metabolism by fluconazole in vitro and in patients with acute promyelocytic leukemia. Biochem.Pharmacol., 1995, 50, 923-928... [Pg.615]

Leo, M.A., S. lida, and C.S. Lieber (1984). Retinoic acid metabolism by a system reconstituted with cytochrome P-450. Arch. Biochem. Biophys. 234, 305-312. [Pg.368]

Abu-Abed, S., G. MacLean, V. Fraulob, P. Chambon, M. Petkovich, and P. Dolle (2002). Differential expression of the retinoic acid-metabolizing enzymes CYP26AI and CYP26B1 during murine organogenesis. Mech. Dev. 110, 173-177. [Pg.524]

Pautus S, Aboraia AS, Bassett CE, Brancale A, Coogan MP, Simons C (2009) Design and synthesis of substituted imidazole and triazole N-phenylbenzo[t/]oxazolamine inhibitors of retinoic acid metabolizing enzyme CYP26. J Enzyme In-hib Med Chem 24 487 98... [Pg.775]

Abu-Abed, S., P. Dolle, D. Metzger, et al. 2001. The Retinoic Acid-Metabolizing Enzyme, Cyp26al, Is Essential for Normal Hindbrain Patterning, Vertebral Identity, and Development of Posterior Structures. Genes Dev 15, no 2 226 0. [Pg.20]

Chapter 1 Retinoic Acid Metabolism, Developmental Functions,... [Pg.286]

Fiorella, P F and Napoli, J L (1991) Expression of cellular retinoic acid binding protein (CRABP) in Escherichia coli characterization and evidence that holo-CRABP is a substrate in retinoic acid metabolism J. Biol Chem 266, 16,572-16,579. [Pg.109]

Fiorella, P D and Napoli, J L (1994) Microsomal retinoic acid metabolism effects of cellular retinoic acid-bmdmg protein (type I) and C18-hydroxylation as an initial step J Biol. Chem. 269, 10,538-10,544... [Pg.109]

Boylan, J. F., Lufkin, T., Achkar, C C, Taneja, R, Chambon, P., and Gudas, L. J (1995) Targeted disruption of retinoic acid receptor alpha (RAR alpha) and RAR gamma results in receptor-specific alterations m retinoic acid-mediated differentiation and retinoic acid metabolism Mol Cell. Biol. 15,843-851... [Pg.426]

However, in retinoic acid-repleted animals the 5,6-epoxide could not be detected at 3 h after injection of [ Hjretinoic acid, possibly owing to the induction of retinoic acid metabolism that lowered the amount of available retinoic acid for subsequent epoxidation (Roberts et al., 1979b Napoli and McCormick, 1981) or to the repressed synthesis of the [ H]5,6-epoxide by endogenous 5,6-epoxide. [Pg.194]

Sigenthaler G, Saurat J-H, Ponec M (1990) Retinol and retinoic acid metabolism relationship to the state of differentiation of cultured human keratinocytes. Biochem J 268 371-378... [Pg.27]

Creech Kraft J, Eckhoff Chr Kochhar DM, Bochert G, Chahoud I, Nau H (1991) Isotretinoin (13-d5-retinoic acid), metabolism, cis-trans isomerization, glucuronidation and transfer to the mouse embryo Consequences for teratogenicity. Teratogen Carcinogen Mutagen 11 21-30... [Pg.116]

See also in sourсe #XX -- [ Pg.38 , Pg.40 ]

See also in sourсe #XX -- [ Pg.38 , Pg.40 ]

See also in sourсe #XX -- [ Pg.38 , Pg.40 ]

See also in sourсe #XX -- [ Pg.185 , Pg.186 , Pg.187 , Pg.188 , Pg.189 , Pg.190 , Pg.191 , Pg.192 , Pg.193 , Pg.194 , Pg.195 ]

See also in sourсe #XX -- [ Pg.442 ]

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