Retinoic acid chemical determination

A considerable amount of work has been reported on the use of MALDI mass spectrometry to examine synthetic polymers. The most popular matrices are DHB, HABA, 1,8,9-trihydroxyanthracene (di-thranol), and all- rans-retinoic acid, doped with a cationization reagent such as copper or silver. The oligomer distribution, the composition of the end groups, the repeat unit, and the nature of any chemical modifications can all be determined if oligomer... 

In this introduction, we do not provide a more detailed review of the classical discoveries in the field of vitamin A research. As already discussed in part, these classical discoveries included the original description of fat-soluble A and the introduction of the term ""vitamin A the recognition of retinol as a substance distinct from its carotenoid precursors the development of quantitative chemical methods for the analysis and assay of retinol and related substances the elucidation of the chemical structure and then the total synthesis of retinol, retinyl esters, and retinoic acid the description of the unique pathology of both hypovitaminosis A and h q)ervitaminosis A in experimental animals and man the elucidation of the fundamental role of retinaldehyde in vision the determination of human and animal needs for retinol or its precursors for adequate nutrition and the development of practical syntheses for the commercial production of retinyl esters to meet those nutritional needs. This historical story has been... 

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