Retinal superoxide

K. Akeo, S. Amaki, T. Suzuki, and T. Hiramitsu, Melanin granules prevent the cytotoxic effects of L-DOPA on retinal pigment epithelial cells in vitro by regulation of NO and superoxide radicals. Pigm. Cell. Res. 13, 80-88 (2000). [Pg.50]

Vitamin A (retinol) is not a classic antioxidant although it is frequently related to a group of antioxidant vitamins E, C, and A. Murata and Kawanishi [83] found that retinol and its derivative retinal induced the formation of 8-HOdG in HL-60 cells. This process was supposedly mediated by hydroxyl radicals formed from hydrogen peroxide (the product of superoxide dismutation) and endogenous transition metal ions. [Pg.841]

Rieger JM, Shah AR, Gidday JM (2002) Ischemia-reperfusion injury of retinal endothelium by cyclooxygenase- and xanthine oxidase-derived superoxide. Exp. Eye Res. 74 493-501. [Pg.77]

G2. Geromel, V., Kadhom, N., Cebalos-Picot, I., Ouari, O., Polidori, A., Munnich, A., Rotig, A., and Rustin, P, Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring die neurogenic ataxia retinitis pigmentosa (NARP) mutation in file ATPase-6 gene of file mitochondrial... [Pg.119]

Activation of microglia by cytokines can produce NO (by iNOS) and superoxide that can diffuse into the neighboring neurones and cause damage. Microglia play an important role in retinal degeneration. In glaucoma, astrocytes in the optic nerve exhibit functional and biochemical characteristics of activation... [Pg.65]

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