Retina-to-blood efflux transport

The experimental methods for evaluating the BRB transport in vivo and the ocular pharmacokinetics of systemic drug administration are relatively straightforward and have been in use for over two decades. Overall, they are useful as a guide for the selection of drug candidates for the treatment of retinal diseases. With the combined use of conventional in vivo methods and newly developed [Pg.334]

Acknowledgments This work was supported, in part, by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science and a grant for Research on Sensory and Communicative Disorders by the Ministry of Health, Labor and Welfare, Japan. The authors thank Drs. T. Terasaki, S. Ohtsuki, M. Obinata, M. Ueda, K. Katayama, T. Kondo, and M. Tachikawa and Messrs. T. Funaki, H. Abukawa, A. Minamizono, T. Nakashima, M. Mori, K. Nagase, and Y. Ohshima for their insights and contributions to ongoing research in the authors laboratory. [Pg.335]

Hosoya and M. Tomi. Advances in the cell biology of transport via the inner blood-retinal barrier Establishment of cell lines and transport functions. Biol. Pharm. Bull. 28 1-8 (2005). [Pg.335]

Cunha-Vaz. The blood-retinal barriers system. Basic concepts and clinical evaluation. Exp. Eye Res. 78 715-721 (2004). [Pg.335]

Harris, D. P. Bingaman, T. A. Ciulla, and B. J. Martin. Retina and choroidal blood flow in health and disease. In S. J. Ryan (ed.), Retina 3rd Edition, Mosby, St. Louis, 2001, pp. 68-88. [Pg.335]

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