Reticulocyte hemoglobin content

Mast AE, Blinder MA, Lu Q, Flax S, Dietzen DJ. Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency. Blood 2002 99 1489-91. 

Stdffman N, Brugnara C, Woods ER. Use of reticulocyte hemoglobin content (CHR) measurement in screening for iron deficiency. J Adolesc Health 2003 32 132. 

Waxman HS, Rabinowitz M. 1966. Control of reticulocyte polyribosome content and hemoglobin synthesis by heme. Biochim Biophys Acta 129 369-379. 

Tsuchiya K, et al. Content of reticulocyte hemoglobin is a reliable tool for determining iron deficiency in dialysis patients. Clin Nephrol 2003 59 115-123. 

Hematological effects Decreased hemoglobin content and hematocrit, and increased total white blood cell counts, reticulocyte counts, and plasma hemoglobin, intravascular hemolysis, anemia and thrombocytopenia... 

FIGURE 76-5. Guidelines for iron therapy in the management of the anemia of chronic kidney disease (CKD). (CHr, content of hemoglobin in the reticulocytes ESA, erythropoietic-stimulating agent Hb, hemoglobin HD, hemodialysis PD, peritoneal dialysis TSat transferrin saturation.)... 

In their second case, one which had previously responded well to both arsenic and liver, Cuthbertson and associates observed that on subcutaneous injection of the amino acids, the clinical condition of the patient became worse. However, after a transfusion, liver therapy produced favorable results. Although tryptophan and histidine produced an early small reticulocyte response in both cases, there was no appreciable increase in the hemoglobin or red cell levels. Thus, even though there are indications that they have some stimulating action on hematopoietic tissue, the results do not justify ascribing the activity of liver to its content of free tryptophane and histidine. Dominici and Penati (27) were also unable to confirm the favorable results of the French authors. 

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