Resveratrol pharmacological activities

The pharmacokinetic dispositions of other stilbenes that are structurally similar to resveratrol and have pharmacological activity across many anticancer, anti-inflammatory, and antioxidant assays have been studied. The pharmacokinetics was characterized in male Sprague-Dawley rats after single intravenous... 

Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998 24 133-138. 

PKSs are characterized by their ability to catalyze the formation of polyketide chains from the sequential condensation of acetate units from malonate thioesters. In plants they produce a range of natural products with varied in vivo and pharmacological properties. PKSs of particular note include acridone synthase, bibenzyl synthase, 2-pyrone synthase, and stilbene synthase (STS). STS forms resveratrol, a plant defense compound of much interest with regard to human health. STS shares high sequence identity with CHS, and is considered to have evolved from CHS more than once. ° Knowledge of the molecular structure of the CHS-like enzymes has allowed direct engineering of CHS and STS to alter their catalytic activities, including the number of condensations carried out (reviewed in Refs. 46, 51, 52). These reviews also present extensive, and superbly illustrated, discussions of CHS enzyme structure and reaction mechanism. 

Das S, Cordis GA, Maulik N, Das DK (2005a) Pharmacological preconditioning with resveratrol role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation. Am J Physiol 288(1) H328-H335... 

Chemoprevention is a strategy used to block or suppress carcinogenesis and degenerative disease using dietary or pharmacological compounds. These chemo-preventive compounds include phenols [such as tm-butyl 4-hydroxyanisole (BHA), t-BHQ (active metabolite of BHA), ethoxyquine, curcumin (from turmeric) and resveratrol (from grapes)] and sulfur compounds [such as oltiplaz, sulforaphane... 

The quality of data was such that even differences in activity between identical compounds supplied by different vendors sufficient to cause them to be misclassified using less rigorous assays could be noted. For example, resveratrol would be identified as active at 2.3 i.M in one sample but inactive in the other, when a 50% threshold is used. The authors suggest that qHTS shifts the analysis of screening data from a statistical to a pharmacological... 

X. Gao, YX. Xu, N. Janakiraman, R.A. Chapman, S.C. Gautam, Immunomodulatory activity of resveratrol Suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production. Biochemical Pharmacology, 62 (9), 1299-1308,2001. 

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