Responsive/switchable surface interaction

Interaction of responsive/ switchable surfaces with cells... 

On the other hand, cells and proteins exhibit space- and time-dependent dynamic changes in their conformations and functionalities in the human body. Since the 1990s, dynamic switchable surfaces have been comprehensively studied in order to control the biomolecular dynamics by modification with smart polymers [6], which show changes in their conformations and properties in response to external stimuli. Among them, thermo-responsive poly(AT-isopropylacrylamide) (PNlPA/ m) is one of the most successful models to control the interaction between biomolecules and the grafted substrates by temperature... 

Like a bulk responsive material, surface of a substrate can be responsive upon electrochemical, photo, temperature, pH, mechanical, or electrical stimuli (Lahann Langer, 2005). Researchers are developing different ways to make these smart surfaces such as self-assembled monolayers (SAMs), polymer brushes, or copolymer coatings. A classic example is a switchable SAM surface in responsive to electric potential, which achieve hydrophobic-hydrophilic transition on a gold substrate. The switchable surfaces provide an idea platform to smdy surface-biological system interactions (Lahann et al., 2003). Polymer brushes and copolymers are more practical avenues to be applied with long-term performance. 

The book provides an overview of recent advances in responsive surfaces and materials designed for biomedical applications. Both bulk responsive materials and surface modification techniques are included. The interactions of biomolecules and cells with responsive interfaces are specifically reviewed, with discussion of emerging applications that could change our lives. The book is divided into two parts with four interdisciplinary topics. The first part reviews switchable and responsive material technologies for biomedical applications (Chapters 1-6). The two topics of Part One are responsive materials and responsive surface modification respectively. Part Two (Chapters 7-11) explores two topics include the interaction of switchable surfaces with proteins and cells, as well as multidispUnary research toward different biomedical applications. 

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