Respiratory chain expression

Scarpulla R. Nuclear control of respiratory chain expression in mammalian cells. J Bioenerg Biomembr 1997 29 109-119. Virbasius J, Scarpulla R. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc Natl Acad Sci 1994 91 1309-1313. 

SECTION 14.5 Nuclear Control of Respiratory Chain Expression... 

The thiazolidinediones have also been reported to act as inhibitors of the respiratory chain at high concentrations, and this appears to account for their ability to activate AMGPK in cultured cells. However, the primary target of the thiazolidinediones appears to be the peroxisome proliferator-activated receptor-y ( PPAR-y), a member of the nuclear receptor superfamily expressed in adipocytes. One of the major effects of stimulation of PPAR-y in adipocytes is the release ofthe... 

Ml 8. Miiller-Hocker, J., Ibel, H., Paetzke, I., Deufel, T., Endres, W., Kadenbach, B., Gokel, J. M., and Hubner, G., Fatal infantile mitochondrial myopathy and myopathy with heterogeneous tissue expression of combined respiratory chain deficiencies. Virchows Arch. A Pathol. Anat. Histopathol. 419, 55-362 (1991). 

At present, direct evidence for the redox control of organellar gene expression, as predicted CORR, is stronger for chloroplasts than for mitochondria (Pfannschmidt et al. 1999). Redox effects on mitochondrial gene expression in vitro are largely confined, at present, to protein synthesis (Allen et al. 1995 Galvis et al. 1998). The search for a direct signalling pathway from the respiratory chain to mitochondrial DNA is likely to be an active area of future research (Allen et al. 2005 Lane 2005). 

Maklashina, E., Berthold, D. A., and Cecchini, G., 1998, Anaerobic expression of Escherichia coli succinate dehydrogenase functional replacement of fumarate reductase in the respiratory chain during anaerobic growth, J. Bacteriol. 180(22) 5989n5996. 

Fig. 1.4. Slipping proton pumps. (A) Simulation of the relationship between electron transfer rate (Jg) and AgH for different degrees of coupling ( ) of an electron transferring proton pump. A/Ih expressed in units Z AGq. (B) Actual experimental results (from Ref. 44 with kind permission from the authors and the copywright owner) for different segments of the mitochondrial respiratory chain as proton pump. Both in (A) and in (B) the rate of electron transfer is varied through titration with an electron transfer inhibitor.

Heat shock protein 70 and c-fos mRNA expression which were escalated during cerebral ischemia were reduced by phthalide 30 [320]. Moreover, 30, 31 and 32 diminished apoptotic neuronal cell death [321], while ameliorating the activities of mitochondrial respiratory chain complexes [322] and choline acetyltransferase (which is related to learning) [323], lending further support for the cerebro-protective potential of these three phthalides against focal ischemia. 

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