Nuclear Control of Respiratory Chain Expression

The synthesis of mitochondrial membranes in which the synthesis of both outer and inner compartments is linked closely to the cell cycle and 

Differentiation of the organelle for respiratory chain phosphorylation, requiring coordinated control of both nuclear and mitochondrial genes. This is independent of cell growth and division. 

The supply of lipids for mitochondrial membrane biosynthesis depends largely on lipids synthesized elsewhere in the cell, especially the endoplasmic reticulum. However, one major lipid component of the inner mitochondrial membrane, cardiolipin (diphosphatidylglycerol), is synthesized within the mitochondria. 

One disorder of mitochondrial transport in humans is due to a failure to transport the methylmalonyl-CoA-mutase precursor protein. The mutation responsible for this disorder affects the signal sequence region. An- 

In addition to limited initiation sites for transcription and the presence of overlapping reading frames, mtDNA has other distinctive features, including a codon assignments that differ from those of nDNA. 

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Scarpulla R. Nuclear control of respiratory chain expression in mammalian cells. J Bioenerg Biomembr 1997 29 109-119. Virbasius J, Scarpulla R. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc Natl Acad Sci 1994 91 1309-1313. 

SECTION 14.5 Nuclear Control of Respiratory Chain Expression... 

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