Resorbable devices

Three-dimensional printing can be used to create resorbable devices with complex concentration profiles within the device (65). This method belongs to solid freeform fabrication methods. Both macrostructure and microstructure can be controlled. The application of this technology for the fabrication of polymeric drug delivery systems has been elucidated. 

Arosio, P., Busini, V., Perale, G., Moscatelli, D. Masi, M. 2008. A new model of resorbable device degradation and drug release - Part I zero order model. Polymer International, 57, 912. 

Aminlashgari, N., Hoglund, O.V., Borg, N., Hakkarainen, M., 2013. Degradation profile and preliminary chnical testing of a resorbable device for ligation of blood vessels. Acta... 

Gottlow J, Guided tissue regeneration using bioresorbable and non-resorbable devices initial heating and long term results , J. Periodontoi, 1993, 64, 1157. 

Perale G, Arosio P, Moscatelli D, Barri V, MUller M, Maccagnan S and Masi M (2009) A new model of resorbable device degradation and drug release transient 1-dimension diffu-sional model. Journal of Controlled Release, 136 196-205. 

The concept of using biodegradable materials for implants which serve a temporary function is a relatively new one. This concept has gained acceptance as it has been realized that an implanted material does not have to be inert, but can be degraded and/or metabolized in vivo once its function has been accompHshed (12). Resorbable polymers have been utilized successfully in the manufacture of sutures, small bone fixation devices (13), and dmg dehvery systems (qv) (14). 

Minabe M, Suzuki F, Umemoto T Intra-pocket antibiotic therapy using resorbable and non-resorbable slow-release devices containing tetracycline. Periodontal Clin Investig 2000 22 14-21. 

Despite advances in hepatocyte culture, tissue engineering of the liver faces significant challenges.One important factor in the development of a self-sufficient hepatic device is vascularization. While in the early stages of development, a device can be maintained by providing sufficient void volume the device ultimately will have to provide for natural supplies of raw materials. This is one of the factors that makes the development of a biodegradable implanted device problematic. Not only must the so-called biodegradable scaffold (and its associated problems) be resorbed... 

Grayson AC, Choi IS, Tyler BM, Wang PP, Brem H, Cima MJ, and Langer R. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat. Mater. 2003 2 767-772. 

Biodegradable or resorbable ceramics 1. As drug delivery devices... 

Polymers are the most versatile class of biomaterials, being extensively used in biomedical applications such as contact lenses, pharmaceutical vehicles, implantation, artificial organs, tissue engineering, medical devices, prostheses, and dental materials [1-3]. This is all due to the unique properties of polymers that created an entirely new concept when originally proposed as biomaterials. For the first time, a material performing a structural application was designed to be completely resorbed and become weaker over time. This concept was applied for the... 

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