Resistance genetic determinants

Cournoyer B, S Watanabe, A Vivian (1998) A tellurite-resistance genetic determinant from pathogenic pseudomonads encodes a thiopurine methyltransferase evidence of a widely conserved family of methyltransferases. Biochim Biophys Acta 1397 161-168. 

Resistance Reduced susceptibility to a chemical that is genetically determined. 

Pyrazinamide is a structural analogue of isoniazid and is converted to the active acid derivative intracellularly by a nicotinamidase. Pyrazinamide resistance has been linked to reduced levels of nicotinamidase but the genetic determinants of resistance have not been fully elucidated. 

Krus S, Zaleska-Rutczynska Z. 1969. Morphological counterparts of the genetically determined resistance of mice to chloroform poisoning. Experientia 26 101-102. 

TABLE 4.6 Quinupristin-Dalfopristin Susceptibility and Genetic Determinants of Resistance in Enterococcus faecium from Different Midwestern U.S. Ecologic Sources... 

Intolerance. Here, a patient shows a qualitatively normal response to the drug, but at an abnormally low dose. This may simply be a resp9nse at the extreme of the normal range of variation. The Gaussian distribution of response to a drug includes individuals who are unusually sensitive as well as those who are resistant. On the other hand, the response to some drugs shows two or more genetically determined populations, e.g. the response to suxamethonium in normal persons and in those with abnormal variants of cholinesterase. 

Gootz TD. The forgotten Gram-negative bacilli what genetic determinants are telling us about the spread of antibiotic resistance. Biochem Pharmacol. 2006 71 1073-1084. 

Bacterial resistance to drugs is genetically determined and is of great clinical importance. 

Ahn, C., CollinS Thompson, D., Duncan, C., and Sites, M.E. 1992. Mobilization and location of the genetic determinant of chloramphenicol resistance from Lactobacillus plantarum caTC2R. 

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