Reservoir drug delivery systems

Reservoir designs, heat pipe, 73 236 Reservoir drug delivery systems, 9 77 Reservoir insulin delivery systems, 9 69 Reservoirs... 

Good, W. R., and Lee, P. I. Membrane-controlled reservoir drug delivery systems, in Medical Applications of Controlled Release, ed. R. S. Langer and D. L. Wise, Vol. I. Boca Raton, CRC Press, 1984, pp. 1-39. 

Figure 9.3 Drug release from a planar membrane-reservoir drug delivery system.

Figure 9.5 Drug release from a cylindrical-reservoir drug delivery system. The cumulative mass of drug released is plotted versus time for cylindrical-reservoir devices with a range of physical characteristics, which are determined principally by the diffusion coefficient for the drug in the polymer and the membrane thickness. In all cases, the overall length of the device, L, and the cross-sectional radius, b, were fixed at 2.7 and 0.5 cm, respectively. In each panel, one of the relevant design parameters was varied (a) hja was varied between 1.2 and 4 with Dj.p = 1x10" and Cl = 20mg/mL (b) Dj.p was varied (for curve A, Dj.p = 5 x 10 cm /s ...

Fig. 2.3 Reservoir- (top) and matrix-based (bottom) drug delivery systems. The matrix system degrades during drug delivery, releasing the drug and matrix through either matrix erosion or degradation.

Figure 4.2 Released amount Qt versus time t plots. Illustration of time lag tL and burst effect tB in a reservoir-type diffusion-controlled drug delivery system.

Cellular reservoirs and anatomical sanctuary sites, such as the CNS, hamper HTV-l treatment and allow HTV-l to persist. To these ends, the SCID mouse model was modified to allow spread of HTV-1 infection betw een human MDM in mouse brain tissue behind an intact BBB. This model permitted comparative assessment of different anti-retroviral drugs by measurements of viral load and numbers of infected human macrophages (Limoges et al., 2000 Limoges et al., 2001). New drug delivery systems across the BBB and novel neuropro tec five therapeutics are under investigation (Persidsky et al., 2001 Dou et al., 2003 Dou et al., 2005). 

A hydrodynamic pressure-activated drug-delivery system can be fabricated by placing a liquid drug formulation inside a collapsible, impermeable container to form a drug reservoir compartment. This is then contained inside a rigid, shape-retaining housing. A laminate of an absorbent layer and a swellable,... 

Urquhart, J. Theeuwes, F. Drug Delivery System Compris- 33. ing a Reservoir Containing a Plurality of Tiny Pills. US... 

Fig. 3 Exploded view of an iontophoretic drug delivery system showing major components top housing, printed circuit board assembly, a bottom housing containing reservoirs for placement of electrodes and hydrogels, and an adhesive laminate. (Diagram from International Patent Publication Number WO 96/39222.)...

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