Uranium reproductive toxicity

Reproductive Toxicity. Recent epidemiological studies have suggested that exposure to radon and radon daughters during uranium mining may be associated with adverse reproductive outcomes (Dean 1981 Muller et al. 1967 Wiese and Skipper 1986). While the evidence of the possible reproductive effects of uranium mining is largely descriptive, reports of alterations in the secondary... 

Arfsten, D.P., Still, K.R., Wilfong, E.R., et al., 2009. Two-generation reproductive toxicity study of implanted depleted uranium (DU) in CD rats. J. Toxicol. Environ. Health Part A 72, 410 27. 

Oral administration of 3 mg uranium/ %/day as uranyl acetate dihydrate to pregnant mice on gestation days 6-15 caused an increase in fetotoxicity (stunted fetuses, external and skeletal malformations, and developmental variations) and maternal toxicity." In reproductive studies, no adverse effects were observed in testicular function or spermatogenesis in male mice treated with up to 80mg/kg/day uranyl acetate dihydrate for 64 days."... 

Domingo, J.L. (2001). Reproductive and developmental toxicity of natural and depleted uranium a review. Reprod. Toxicol. 15 603-9. 

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