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Reporter genes, estrogen bioassays

Schreurs RHMM, Sonneveld E, Jansen JHJ, Seinen W, van der Burg B. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci 2005 83 264-72. [Pg.409]

Scientists at the National Institute of Environmental Health Sciences report that a set of three existing tests, when used in combination, provides a rapid assessment of a chemical s potential to mimic the hormone estrogen. One test determines whether the chemical can bind to an estrogen receptor site the second determines whether it activates estrogen-responsive genes in a cell hne and the third determines whether the chemical causes the proliferation of estrogen-responsive uterine tissue in female mice. Using these tests, results can be obtained in 3-5 weeks at a cost of about 15,000, versus 1-2 million for conventional cancer bioassays. ... [Pg.483]

See other pages where Reporter genes, estrogen bioassays is mentioned: [Pg.69]    [Pg.927]    [Pg.937]    [Pg.11]    [Pg.98]    [Pg.116]    [Pg.396]    [Pg.181]    [Pg.527]    [Pg.69]    [Pg.44]   
See also in sourсe #XX -- [ Pg.247 ]



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