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REP, Rab escort protein

Scheme 2 Intracellular processing of Rab proteins. Rab proteins form a complex with REP (Rab escort protein) that Is subsequently recognized by Rab GGTase-II and leads to geranylgeranylation of Rab. Scheme 2 Intracellular processing of Rab proteins. Rab proteins form a complex with REP (Rab escort protein) that Is subsequently recognized by Rab GGTase-II and leads to geranylgeranylation of Rab.
Prenylated small GTPases represent major hubs in most membrane-connected signaling networks. Rab prenylation is mediated by Rab geranylgeranyl transferase (RabGGTase), which works together with an adaptor protein, Rab escort protein (REP). Rab cycling between membranes and the cytosol is made possible by interaction with the GDP dissociation inhibitor (GDI). Both GDI and REP function as molecular chaperones, which can solubilize the prenylated Rab proteins in the cytosol. [Pg.85]

See other pages where REP, Rab escort protein is mentioned: [Pg.579]    [Pg.46]    [Pg.321]    [Pg.463]    [Pg.579]    [Pg.46]    [Pg.321]    [Pg.463]    [Pg.171]    [Pg.181]    [Pg.48]    [Pg.70]    [Pg.549]    [Pg.87]    [Pg.162]   
See also in sourсe #XX -- [ Pg.549 ]



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Rab escort protein

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