Renal function cyclooxygenase-2 inhibitor effects

There is no evidence that short-term use of cyclooxygenase inhibitors has any major deleterious effect on renal function in healthy individuals. 

There is no evidence that short-term use of single cyclooxygenase inhibitors has any major deleterious effect on renal function in healthy, non-hypovolemic individuals, but even short-term use of a compound of this class is never a guarantee that nephropathy will not occur. 

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