Relative Merits of Explicit and Implicit Solvent Models

5 Relative Merits of Explicit and Implicit Solvent Models 

The fundamental difference between the explicit and implicit solvent models is not that one has solvent and the other does not. Rather, the difference is that the implicit model employs a homogeneous medium to represent tlie solvent where the explicit model uses atomistically represented molecules. While tlie latter choice is clearly tlie more physically realistic, the practical limitations imposed by explicit representation dictate that it is not necessarily the best choice for a given problem of interest. This section compares and contrasts the relative strengths and weaknesses of tlie two models, including some illustrative applications. 

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RELATIVE MERITS OF EXPLICIT AND IMPLICIT SOLVENT MODELS... 

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