Rel Homology Domain

Rel homology domain (RHD) that encompasses a sequence-specific DNA-binding domain, a dimerization domain and a nuclear translocation signal (NLS) (Fig. la). RelA, cRel, and RelB contain a transcription activation domain (TAD). NF-kB 1 and NF-kB2 are synthesized as large precursors, pi 05 and pi 00, that are posttranslationnally processed to generate the mature forms, p50 and p52, which lack a TAD. 

The Rel homology domain (RHD) is an evolutionarily conserved domain found in some eukaryotic transcription factors, including NF-kB, the nuclear factors of activated T-cells (NFATs) and the drosophila proteins Dif and Relish. Some of these transcription factors form... 

Family of transcription factors that modulate the expression of genes which control immune, inflammatory, and acute-phase responses, as well as cell growth, responses to stress, apoptosis, and oncogenesis. All members of this family have a Rel-homology domain that contains sequences responsible for dimerization and DNA binding. In vertebrates, this family includes NF-kB1 (also known as p50), NF-kB2 (also known as p52), Rel (also known as cRel), Rel-A (also known as p65), and Rel-B. 

Essential for induction ofthe/Z-5 gene in inflammatory reactions is the binding site for nuclear factor kappa B (NF-kB). NF-kB responds to cytokines, stress, free radicals, ultraviolet irradiation, and bacterial, viral, or even parasitic antigens [2]. NF-kB stands for a family of subunits, which form homo-, and heterodimers. All NF-kB proteins share a highly conserved DNA-binding/dimerization domain called the Rel homology domain (RHD) consisting of two (3-strand core domains... 

Decoville, M., Giraud-Panis, M.J., Mosrin-Huaman, C., Leng, M., and Locker, D. (2000) HMG boxes of DSPl protein interact with the rel homology domain of transcription factors. Nucleic Acids Res. 28, 454-462. 

Sequence - s pec i fic ON A binding domain oligomerization domain PCNA binding domain/poleniial N1 -S Rel homology domain calmodulin binding domain... 

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