Regulation of Solvent Formation in C. acetobutylicum

The transcriptional repressor Rex is a redox-sensing protein playing a role in the shift from acidogenesis to solventogenesis in C. acetobutylicum [102]. Rex controls the expression of butanol biosynthetic genes in response to NADH/NAD ratio in the cell [102,103]. Rex is also present in C. beijerinckii [103] and in C. saccharobutylicum as well as C. saccharoperbutylacetonicum (BLAST analysis using JGI/IMG website). [Pg.345]

The catabolite control protein A (CcpA) is a pleiotropic regulator involved in the regulation of many different cellular processes in C. acetobutylicum [104,105]. [Pg.345]

The transcription factor AdcR binds upstream of the adc and sol operons and seems to play a role in solvent production [107,123]. Its detailed function is yet to be characterized. [Pg.346]

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