Regulates Axin Protein Levels by Inhibiting Tankyrases

XAV939 Regulates Axin Protein Levels by Inhibiting Tankyrases 

Affinity chemical proteomics relies on the affinity capture of the cellular efficacy targets onto solid support. Therefore, it is critical to introduce a linker 

18 proteins were significantly and specifically competed-off ( 65%, 2cr of the mean) with soluble XAV939, including the poly(ADP-ribose) polymerases PARPl, PARP2, tankyrase 1 (TNKSl), tankyrase 2 (TNKS2), and several known PARPl substrates, presumably co-purified with PARPl [22]. 

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