Reflection Multiplicity

There ate many classes of anticonvulsant agent in use, many associated with side effect HabiUties of unknown etiology. Despite many years of clinical use, the mechanism of action of many anticonvulsant dmgs, with the exception of the BZs, remains unclear and may reflect multiple effects on different systems, the summation of which results in the anticonvulsant activity. The pharmacophore stmctures involved are diverse and as of this writing there is htde evidence for a common mechanism of action. Some consensus is evolving, however, in regard to effects on sodium and potassium channels (16) to reduce CNS excitation owing to convulsive episodes. 

Transition metal oxides show a broad structural variety due to their ability to form phases of varying metal to oxygen ratios reflecting multiple stable oxidation states of the metal ions... 

Individual mice express a combinatorial pattern of MUPs (typically at least 7-12 isoforms) reflecting multiple allelic variants and multiple expressed loci (Robertson et al. 1997). Among wild mice, individuals each express a different pattern even when captured from the same population (Payne, Malone, Humphries, Bradbrook, Veggerby, Beynon and Hurst 2001 Beynon et al. 2002), with the exception of very closely related animals that have inherited the same haplotypes from their parents (a 25% chance among outbred sibs, similar to MHC type sharing). The extreme heterogeneity in the sequence of MUPs is mostly confined to strands B, C and D and the intervening turns of the 8-barrel structure (Beynon et al. 2002). 

Once formed, the LNAPL is referred to as a pool that is really a continuous accumulation of LNAPL. Subpools are individual accumulations of relatively uniform free-product types based on geochemistry (API gravity, specific constituents, isotope ratios, etc.) that have coalesced, reflecting multiple-source accumulations with time. The LNAPL pool, once formed, also maintains a capillary fringe. The anticipated capillary rise of LNAPL can be calculated as follows ... 

This theory was further explored in an anaesthetised pig model, which facilitated portal vein and bile sampling [86], However, the hepatic extraction ratio and the biliary clearance of fexofenadine were unaffected by verapamil in the pig model. The question as to why verapamil/ketoconazole increase the fraction absorbed (i.e. based on appearance kinetics) and yet the fraction absorbed estimated on the basis of disappearance kinetics (i.e. /err) for the intestinal segment appears unchanged remains to be explored and most likely reflect multiple interplay between absorptive and efflux drug transporters in the intestinal tissue. 

Mushiake, H., Saito, N., Sakamoto, K., Itoyama, Y., and Tanji, J. (2006). Activity in the lateral prefrontal cortex reflects multiple steps of future events in action plans. Neuron 50, 631—641. Newell, A., and Simon, H. A. (1972). Human Problem Solving. Prentice-Hall, Englewood Cliffs, NJ. Passinsrham, R. E. (1993). The Frontal Lobes and Voluntary Action. Oxford University Press, Oxford, UK. 

G8. Gould, J. H., Construction and use of reflecting multiple-pass absorption cells for the ultra-violet, visible and near-infra-red. Appl. Spectrose. 25, 103-105 (1971). 

Now, the modeling class, K,3di, .ji,p p rtionation. fully recognized and usable by K. An evaluation of K 3ji, i,p, p rtiona.ion R. and Rz will return an instance of the class reaction or set of instances (reflecting multiple favored products). Each reaction constructed will contain values for the attributes (e.g., reactants, products, stoichiometry, reaction-environment, enabling conditions) as specified by the modeling element reaction (see Section II.A). 

As with other organisms, PCB residue levels in humans reflects multiple exposure pathways, and congener-specific elimination. PCB profiles in human serum immediately following exposures reflect the profiles in the exposure sources however, selective metabolism and excretion begin to alter the congener profile within 4-24 hours (Hansen 1999). Thus, in most cases, the PCB profile in adults represents a steady state body burden which does not match the profile of commercial PCB formulations (Aroclors, etc.). For example, neither the PCB profile of human adipose nor of a composite human milk sample resemble the pattern of any commercial PCB formulation (Jensen and Sundstrom 1974 Safe et al. 

The crystal and molecular structure of [MoOCl(CNMe)4]l3 has been determined and the short Mo—O length 163.6(37) pm reflects multiple-bond character. ... 

Specific virus reduction values achieved with each individual viral removal/inactiva-tion step are cumulative, so that the final viral reduction value attained reflects multiple removal and/or inactivation procedures occurring throughout the process. In summary, the processing of rAHF-PFM is associated with a significant viral reduction capacity for both lipid-enveloped and non-lipid-enveloped viruses and provides additional assurances of reliability with respect to pathogen safety. 

The absence of CIDNP resulting from pairs R -MgX speaks against -MgX as an intermediate in solution [511. The observed CIDNP reflects multiple effects front [R- R- pairs only. (R- -MgX would have a non-/m> value of Ag and would give rise to net effects, which arc mu seen. However, it is conceivable that R- -MgX pairs do not generate C lDNP Ag eould be so large that CIDNP is attenuated. or -MgX eould remain at the surface where a metallic shielding effect prevents CIDNP, etc. 

Spin delocalization in the two pentachlorophenyl rings is high, as shown by the value of the esr linewidth (4.0 G) (which reflects multiple couplings with chlorines) about three times that in the radical PTM- (1.4 G) and similar to that of the radical PPF- (4.7 G)). 

Because hemoglobin has four subunits, its binding of oxygen can reflect multiple equilibria ... 

---