Reference agent

Table 3 Receptor binding for selected chemical agents using anandamide and THC as references. Agents 11-15 are especially preferred...

Table 2 DPP-IV inhibitor effectiveness measured by plasma glucose lowering after dosing fasted male diabetic fatty Zucker rats with 3 (xmol/kg with either an experimental or reference agent...

Table 3 The effect of experimental agents, Entries 4 and 7, and reference agent, 9,ll-dideoxy-9a, 1 la, methanoepoxy prostaglandin F2c on canine intraocular pressure at predetermined times after dosing...

Table 2 Antitumor activity of tricyclic 6-(2-dimethylamino-ethylamino) derivatives against in vitro growth of colorectal cancer. The reference agent, (I), is provided Table 1...

TABLE 1. Testing results for etching rates for experimental terpolymer (I) and two reference agents. Higher etching levels are preferred. 

In developing an RRA, the specificity of the system is shown by demonstrating that reference agents, known to interact with R, inhibit the binding of L. With the increasing reliance on cloned and expressed receptor systems, this latter step is crucial since expression of receptors in bacterial or mammalian... 

Final assay volumes are 0.5-1.0 ml. Incubations are generally performed using triplicate tubes, each of which contains identical amounts of ligand, tissue, sample, or reference agent. In the case of sample tubes, it is useful to include at least two, and better yet, three different amounts of sample in triplicate in order to ensure the final result falls in the range of the reference curve. 

If the identity of the substance of interest is known, extrapolation to the x-axis yields the precise concentration of substance in the sample. As shown in Figure IB, the amount of reference agent added to each tube of the standard curve can be expressed as either a concentration or an absolute amount. If the identity of the substance is unknown, as may be the case when screening for novel chemicals in natural product extracts, an arbitrary value is assigned to describe compound activity. 

First author (References) Agents Toxicity Treatment Results... 

References Agents Primary tumor Patients Survivai rates... 

Reference agent Silica Silica Fatigue test mode (MPa m ) (MPa m )... 

The findings comparing the antagonist activity of oxilorphan, levo-BC-2910 and several reference agents are summarized in Table I below... 

Narcotic Antagonlac and AgonliC (Analgesic) Activity of Oxilorphan, levo-BC-29IO and Reference Agent ... 

Sun et al. [39] synthesized 7-alkyloxy-4, 5-dihydro-imidazo[l,2-a]quinoline derivatives and studied their antimicrobial activity. Most of the compounds exhibited potential antibacterial activity against gram-negative and gram-positive bacteria. The compound (7-heptyloxy-4,5-dihydro-imidazo[l,2-ajquinoline) showed excellent activity than that of reference agent Ciprofloxacin. 

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