Recruitment scaffolds

While RGS recruitment seems to be independent of the activation state of either receptor or G protein, there is evidence that RGS proteins can bind directly to GPCRs (111). It is possible that the receptors act as scaffolds serving to bring RGS proteins nearer to the G protein targets (112). Thus, RGS proteins may be selectively sorted at the plasma membrane by receptors to orient and optimize their GAP activity toward the linked Ga. 

Ryadnov, M. G., and Woolfson, D. N. (2004). Fiber recruiting peptides Noncovalent decoration of an engineered protein scaffold. / Am. Chem. Soc. 126, 7454-7455. 

The node ofRanvier, paranodal junctions and the adjacent juxtaparanodal regions each contain distinct protein complexes. Each of these membrane domains contains a specific set of cell adhesion molecules that are stabilized and retained through interactions with cytoskeletal and scaffolding proteins. These in turn recruit and stabilize the appropriate channels (Coman et al., 2005 Simons and Trajkovic, 2006). 

P 4 SID protein, 290-292 P 10 promoter, 9 P22 scaffolding protein chemistry of, 280-281 coat protein binding in, 277—279 domain strncmre of, 274 fnnctional domains of, 274—280 minor proteins, recruitment of, 276-277 oligomerization of, 275—276 procapsid exit in, 279—280 role of 272-274... 

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