Reconstitutional modification, myoglobin

Semi-synthetic enzymes are produced by the reconstitution of apo-proteins with artificial active sites that yield novel catalytic functions [237]. For example, reconstitution of apo-myoglobin with Co(II)-protoporphyrin IX results in a novel biocatalyst that is capable of hydrogenating acetylene derivatives or evolving hydrogen [209, 238]. By the modification of the reconstitution of apo-proteins with artificial redox-active cofactors and the covalent attachment of photosensitizer units, photo-... 

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