Recommendations and Reference Intervals

The measurement of the urinary clearance of inulin, after continuous infusion, is considered the primary or reference method for the determination of GFR. However, because the necessary plasma and urine assays for inulin often are not practical in clinical laboratories, plasma creatinine or creatinine clearance has almost universally been used for assessment of GFR. With increasing recognition of the importance of early detection and management of GKD, 

In practice, there may be little to choose between the Cockcroft and Gault formula and the more recently described MDRD equation,and which is chosen will be 

TABLE 24-3 Glomerular Tiltration Rate Reference Values  

Abrahamson M, Grubb A, Oiafsson I, Lundwall A. Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine pro- 

Agency for Healthcare Research and Quality. Evidence Report/Technology Assessment No. 84, Use of glycated hemoglobin and microalbuminuria in the monitoring of diabetes mellitus. 2003. Available at www.ahrq.gov 

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