Recognition negative

The file Is used routinely In the laboratory at the National Institutes of Health In an attempt to explain abnormal test results The resident physicians affiliated with the Clinical Chemistry Service discuss the results with the patient-care physicians and determine If the results were due to the patient s clinical state or to a drug effect This close monitoring of test results has led to recognition of deficiencies In what Is believed are specific enzymatic procedures for the measurement of glucose and uric acid Likewise, the gualac procedure for occult blood In feces was found to yield false negative results under certain circumstances This has prompted the development of a more specific procedure (Jaffe et al unpublished) ... 

Fig. 11. Amide F thermal denaturation spectra for ribonuclease A as followed by FTIR (left) and VCD (right), which show the IR peak shifting from the dominant /3-sheet frequency (skewed with a maximum at 1635 cm-1) to the random coil frequency ( 1645-1650 cm-1) and the VCD shape changing from the W-pattern characteristic of an a + p structure to a broadened negative couplet typical of a more disordered coil form. The process clearly indicates loss of one form and gain of another while encompassing recognition of an intermediate form. (This is seen here most easily as the decay and growth back of the 1630 cm-1 VCD feature, but is more obvious after factor analysis of the data set, Fig. 15).

Ulevitch, R.J. and Tobias, P.S. (1999) Recognition of gram-negative bacteria and endotoxin by the innate immune system. Current Opinion in Immunology 11, 19-22. 

Odorant recognition initiates a second-messenger cascade leading to the depolarization of the neuron and the generation of action potentials 821 Negative-feedback processes mediate adaptation of the olfactory transduction apparatus to prolonged or repetitive stimulation 823 Alternative second-messenger pathways maybe at work in olfactory transduction 823... 

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