Donor-acceptor selectivity, reciprocal

B. Fraser-Reid, J. C. Lopez, K. V. Radhakrishnan, M. V. Nandakumar, A. M. Gomez, and C. Uriel, One pot/two donors/one diol give one differentiated trisaccharide Powerful evidence for reciprocal donor-acceptor selectivity (RDAS), Chem. Commun., (2002) 2104—2105. 

Fraser-Reid B, Lopez JC, Gomez AM, Uriel C. Reciprocal donor acceptor selectivity (RDAS) and Paulsens concept of match in saccharide coupling. Eur J Org Chem 2004 1387-1395. 

Reciprocal Donor Acceptor Selectivity (RDAS) and insitUj Double Differential Glycosidations... 

The results in Schemes IS and 16a suggest that there is a mutual preference of each donor for each-OH. For example, the secondary-OH of 87 or 90 chooses the armed donor, and vice versa i.e. the armed donor chooses the secondaiy-OH. In other words there is Reciprocal Donor Acceptor Selectivity (RDAS). 

Reciprocal dtmor acceptor selectivity (RDAS) a new concept for matching donors with acceptors. Can J Chtan 80 1075-1087... 

The retention characteristics of over 40 small polar molecules (phenols, phenyl alcohols, imines, phenylcarboxylic acids, phenyl esters, phenyl. ethers, phenyl ketones, nitro- and cyanophenols) were studied on C4 and C g stationary phases [117]. Experimental results explain the advantages of methanol over other organic mobile phase components (e.g., acetonitrile) in the separation of aliphatic alcohols, phenols, and carboxylic acids. Methanol, through its reciprocal hydrogen bond donor/acceptor character forms stable complexes with these solutes in the stationary phase, giving enhanced selectivity for these solute types. The k values for these 40 solutes are tabulated for 20/80, 25/75, and 50/50 methanol/water mobile phases. 

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